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KMID : 0361620160510060503
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Journal of the Korean Orthopaedic Association
2016 Volume.51 No. 6 p.503 ~ p.508
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Synovial Sarcoma of the Extremities
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Moon Jang-Yong
Chung So-Hak
Oh Sun-Ju
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Abstract
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Purpose: Synovial sarcoma is an uncommon malignant soft tissue tumor mostly prevalent in young adults. Previous studies analyzing the prognostic factors have been limited due to the inclusion of heterogenous cohorts of patients with nonextremity and recurrent tumors. The purpose of this study was to determine the independent prognostic factors for the treatment methods associated with local recurrence and metastasis of primary synovial sarcoma localized to the extremities.
Materials and Methods: Between April 1999 and June 2014, a total of 79 patients were diagnosed with synovial sarcoma, of which 73 underwent wide excision at Kosin University Gospel Hospital and were followed-up for 60 months (24-72 months). The analyzed prognostic factors were treatment methods for local recurrence and metastasis during the postoperative follow-up period. The Cox regression model was used for multivariate analysis.
Results: For local recurrence according to the treatment methods, 9 recurrences occurred in 9 surgical treatments, 8 in 20 chemotherapy added surgical treatments, 13 in 20 radiotherapy added surgical treatments, and 4 in 24 chemotherapy with radiotherapy added surgical treatments. For metastasis according to the treatment methods, 9, 5, 12, and 2 metastases occurred respectively. Chemotherapy had statistical significance in multivariate analysis (p<0.0001).
Conclusion: Adjuvant chemotherapy can be useful for the treatment of synovial sarcoma.
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KEYWORD
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synovial sarcoma, therapy, survival rate, local neoplasm recurrence, neoplasm metastasis
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